Reply to setup with multiple laptops

Hey guys quick question.

If i have my s4 mapped out to my macbook pro laptop with TP2, and my friend wants to borrow it to map it out with his Windows laptop with TP2, will him borrowing it and mapping it out for his laptop effect any settings when i plug it back into mine? I'm a big hesitant to be lending it out in case is effects my settings at all.

cheers