Reply to Should I get over my prejudice/ignorance/snobbery for WAV and change to mp3?

A combination of audiophile snobbery, ignorance, prejudice and an ability to convince myself that I CAN hear the difference has resulted in me only buying WAV files from Beatport and JunoDownload. I am also fortunate enough to have a 500GB ASUS NJ61 that only has my (stripped) OS, Traktor and music library on it. Our currency is about to hit 8 Rands to 1 Dollar and I am reconsidering the cost of WAV upgrades. I've read the science (I'm sick of reading about WAV's "voracious appetite for disc space" and "once lost with compression, always lost to compression") but want to hear from this community.
1. Is WAV REALLY worth it?
2. Will I notice the difference?
I really appreciate the sound quality of the S4 and don't want it compromised.