Reply to Mobile DJ Gig advice needed!

Let me preface this by saying that I have been playing clubs and college parties for the last two years... but by no means am I an "expert" in mixing. I can craft and keep a dance floor but my audience has usually been drunk college kids.

This weekend I have my first large scale (1500-2000) mobile dj event with ages ranging from 22 all the way up to late 60's. The request list they have filled out includes a large variety of songs spanning multiple decades/styles/bpms.

What is the community's thoughts on how to craft the evening ?

Any advice is greatly appreciated!